Farnesoid X receptor via Notch1 directs asymmetric cell division of Sox9+ cells to prevent the development of liver cancer in a mouse model
Abstract Background Asymmetrical cell division (ACD) maintains the proper Soft Toy number of stem cells to ensure self-renewal.The rate of symmetric division increases as more cancer stem cells (CSCs) become malignant; however, the signaling pathway network involved in CSC division remains elusive.FXR (Farnesoid X receptor), a ligand-activated tran